SPM Active® is a remarkable supplement. The incredible thing about Specialised Proresolving Mediators (SPM) is that they change the way inflammation is expressed in the body. They shift inflammation from an initiation phase to a resolving phase. That sets your body on the path to stopping inflammation at its core. Remarkably, we derive SPM Active® from fish oil, good old natural Omega-3.
Appreciate that while SPM Active®comes from Omega-3, it is not the same as Omega-3, You’re not going to get the benefits of SPM Active® by taking Omega-3. You have to take the real thing. Order your SPM Active® here.
Chronic Inflammation
Inflammation is the body’s natural response to injury, infection, or stress. Acute inflammation is short-term and helps the body heal. However, chronic inflammation is a persistent, low-grade state of immune activation. Chronic inflammation negatively impacts overall health, including brain function. Chronic inflammation releases chemicals called pro-inflammatory cytokines (e.g., IL-6, TNF-α, and CRP), which affect the brain. For instance, these cytokines can alter neurotransmitter systems, such as serotonin and dopamine, which are critical for mood regulation.
When you have a stroke or brain injury, inflammation invariably occurs. Indeed, cerebral inflammation occurs with any form of neuropathology. However, when it comes to the brain, inflammation is a two-way street. While some conditions cause inflammation (like concussion), in other conditions inflammation promotes the disease (like Alzheimer’s disease).
Inflammation and Mood Disorders
Furthermore, it’s not just physical trauma that leads to inflammation, but emotional trauma too. We find inflammation in the brain in individuals with depression and anxiety. Cerebral inflammation impairs communication between neurons. In turn, that disrupts the brain’s ability to regulate mood and emotions.
Chronic psychological stress can activate the body’s immune system, increasing inflammation. The hypothalamic-pituitary-adrenal (HPA) axis, a key player in the stress response, can become dysregulated. That leads to both heightened inflammation and exacerbated symptoms of anxiety and depression. Studies show higher levels of inflammatory markers (like CRP) in people with depression compared to those without. Similarly, people with anxiety disorders have elevated inflammatory markers.
When inflammation doesn’t resolve properly, it becomes chronic. That leads to ongoing pain (both physical and mental), tissue damage, and a host of health problems. This is where Specialized Pro-Resolving Mediators (SPMs) come in.
What Are SPMs like SPM Active®?
SPMs are molecules that come from Omega-3 fatty acids like EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid). Either your body produces them or Metagenics manufactures them. 😊 They act as signals in the body, promoting the resolution of inflammation without suppressing it entirely. Unlike painkillers or anti-inflammatory drugs that block the inflammatory process, SPMs actively help the body return to a state of balance after inflammation has done its job.
How SPMs Work
The acute inflammatory response consists of two phases: initiation and resolution. Previously, we thought resolution was a passive process, simply dilution of chemoattractants. However, we now know that resolution is an active, biologically programmed response. We have discovered a class of signalling molecules (SPMs) that use Omega-3 fatty acids to produce structurally distinct substances. There are three types of signalling molecules — resolvins, protectins and maresins. Collectively we call these specialized pro-resolving mediators (SPM’s). Their job is to flip a biochemical switch that shifts inflammation from initiation to resolution.
SPMs limit white blood cell (neutrophil) migration and enhance macrophage clean up. Macrophage biosynthesis of a specific SPM maresin (MaR1) results in potent pro-resolving and tissue regenerative activity. This stimulates a macrophage phenotype switch from M1 to M2. The change triggers reparative and anti-inflammatory macrophage functions.
In short, SPMs don’t stop inflammation from occurring. Instead, they turn off excess inflammation. SPMs signal immune cells to stop producing pro-inflammatory compounds when they’re no longer necessary. SPMs promote tissue repair by clearing out cellular debris and regenerating tissue. Additionally, SPMs help to alleviate pain by resolving the inflammation at its source rather than masking it. Consequently, SPMs are a natural and safe way to address chronic inflammation and support long-term health.
The Benefits of SPM Active® for Inflammation
SPM Active® is particularly beneficial for individuals dealing with conditions linked to chronic inflammation, such as:
- Autoimmune disorders (e.g. multiple sclerosis, sarcoidosis, systemic lupus erythematosus)
- Brain injury and stroke
- Joint pain and arthritis, especially rheumatoid arthritis
- Cardiovascular issues (especially atherosclerosis)
- Mood disorders (particularly anxiety and depression)
- Muscle recovery after sports injury
- Neurodegenerative conditions (like Alzheimer’s and vascular dementia)
- Neuroinflammation (such as vasculitis, anti-phospholipid syndrome)
By resolving inflammation rather than suppressing it, SPM Active® helps your body heal more effectively while reducing the risk of side effects often associated with conventional anti-inflammatory drugs. Order your SPM Active® here.
SPMs vs. Cox-2 Inhibitors
Cox-2 inhibitors are the mainstream anti-inflammatory drugs. They block the action of cyclooxygenase (COX-1 and COX-2), which are enzymes that produce prostaglandins. Prostaglandins are lipids that trigger inflammation and swelling and contribute to pain by sensitizing nerve endings.
While Cox-2 inhibitors can be effective for short-term pain relief, they have several limitations. They can cause gastrointestinal issues, increase the risk of cardiovascular events, and disrupt kidney function. Furthermore, they suppress inflammation rather than resolving it. These drugs delay resolution. They stop the inflammatory process but don’t help the body transition back to a healthy, balanced state.
SPM Active® offers a safer alternative because it works with your body’s natural processes. There is no interference with the beneficial aspects of inflammation, like fighting infection or injury. SPM Active® is naturally derived and mimics compounds already produced by the body. SPM Active® supports long-term healing by addressing the root cause of inflammation.
Why Consider SPM Active® by Metagenics?
Metagenics SPM Active® is a premium supplement that delivers concentrated doses of SPMs, helping your body naturally manage inflammation. Its benefits include:
- Faster Recovery. It is ideal for athletes or anyone recovering from injury or surgery.
- SPM Active® reduces chronic pain without the risks associated with NSAIDs or Cox-2 inhibitors.
- SPM Active® supports the immune system by resolving inflammation effectively.
- It is natural and safe since it is derived from purified fish oil, making it a clean and sustainable choice.
Take Control of Chronic Inflammation
If you’re struggling with inflammation-related health issues or looking for a safer, more natural way to support your recovery, SPM Active® might be the solution you need. By working with your body’s natural healing mechanisms, SPM Active® offers a breakthrough approach to achieving long-term wellness without relying on medications with harmful side effects.
Please order your SPM Active® here. Apologies in advance if Metagenics is out of stock. Unfortunately, they struggle to keep up with demand.
